Journal article

MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry

James L Leach, James Roebker, Austin Schafer, Joshua Baugh, Brooklyn Chaney, Christine Fuller, Maryam Fouladi, Adam Lane, Renee Doughman, Rachid Drissi, Mariko DeWire-Schottmiller, David S Ziegler, Jane E Minturn, Jordan R Hansford, Stacie S Wang, Michelle Monje-Deisseroth, Paul G Fisher, Nicholas G Gottardo, Hetal Dholaria, Roger Packer Show all



BACKGROUND: This study describes imaging features of diffuse intrinsic pontine glioma (DIPG) and correlates with overall survival (OS) and histone mutation status in the International DIPG Registry (IDIPGR). METHODS: Four hundred cases submitted to the IDIPGR with a local diagnosis of DIPG and baseline MRI were evaluated by consensus review of 2 neuroradiologists; 43 cases were excluded (inadequate imaging or alternative diagnoses). Agreement between reviewers, association with histone status, and univariable and multivariable analyses relative to OS were assessed. RESULTS: On univariable analysis imaging features significantly associated with worse OS included: extrapontine extension, large..

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Funding Acknowledgements

Supporting foundations include: The Cure Starts Now Foundation, Julian Boivin Courage for Cures Foundation, Hope for Caroline Foundation, The Cure Starts Now Australia, Aidan's Avengers, Austin Strong, Brooke Healey Foundation, ChadTough Foundation, Cure Brain Cancer, Grant's Ginormous Gift, Jeffrey Thomas Hayden Foundation, Love Chloe Foundation, Musella Foundation, Operation Grace White, Pray Hope Believe Foundation, Reflections of Grace, Ryan's Hope, Storm the Heavens Fund, Benny's World, Julia Barbara Foundation, Lauren's Fight for Cure, Lily Larue Foundation, The Isabella and Marcus Foundation, Canadian Children's Brain Cancer Foundation, Danni Kemp Cancer Support Fund, Smile for Brooklyn, The Gold Hope Project, Abbie's Army, Michael Mosier Defeat DIPG Foundation, Soar With Grace Foundation, The Jones Family Foundation, Smiles for Sophie Foundation, A Cure from Caleb Society, Wayland Villars DIPG Foundation, American Childhood Cancer Organization, Juliana Rose Donnelly Trust, Sheila Jones & Friends, The Ellie Kavalieros DIPG Research Fund, Voices Against Brain Cancer, and The DIPG Collaborative as well as the Kyler Strong Foundation and Keris Kares. We also acknowledge the support of the Child Health Research Institute, Stanford University.