Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery

PJ Devereaux; A Ciapponi; M Dieguez; A Granel; S Barratt; D Beilby; S Bolsin; J Grant; R Kerridge; J Love; T McCulloch; P Myles; M Paech; P Peyton; M Priestley; R Halliwell; M Reeves; J Varigos; D Wolfers; D de Albuquerque; AC do Amaral Baruzzi; C Blacher; L Carlos Bodanese; J Pericles Esteves; M Lucio Alves Bapista Filho; L Eduardo Guiselli Gallina; N Mitsuru Izukawa; L Nigro Maia; J Antonio Marin-Neto; O Ribeiro Franca Neto; R Rabello; P Henrique Penha Rosateli; J Francisco Kerr Saraiva; N Ali; N Badner; C Baer; S Beattie; H Bertozzi; D Brunet; G Bryson; J Campeau; D Chauret; D Cook; D Cook; B Davies; G Doak; G Doig; G Dresser; P Duffy; A Findlayson; W Ghali; K Gilbert; D Hughes; M Jacka; C Kamra; M Khurana; L Lanthier; D Lazaric; C MacDonald; P MacDonald; J Marti; R Martinek; R Merchant; D Miller; J Misterski; R Mizera; J Morin; J Parlow; J Paul; M O'Reilly; J Ostrander; S Rammohan; C Rosen; T Schricker; S Sivakamaran; M Turabian; D Twist; J VanVlymen; B Warriner; D Wong; K Zarnke; W Chen; WZ Chen; JY Cui; LL Deng; WJ Hu; W Guan; B Jiang; HY Li; J Li; X Li; Z Li; HL Liu; JH Liu; LH Liu; YD Liu; SP Ma; FX Ren; L Sun; CP Wang

Journal article

Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery

PJ Devereaux, A Ciapponi, M Dieguez, A Granel, S Barratt, D Beilby, S Bolsin, J Grant, R Kerridge, J Love, T McCulloch, P Myles, M Paech, P Peyton, M Priestley, R Halliwell, M Reeves, J Varigos, D Wolfers, D de Albuquerque Show all

American Heart Journal | Published : 2006

DOI: 10.1016/j.ahj.2006.05.019

Abstract

Background: Noncardiac surgery is associated with significant cardiovascular mortality, morbidity, and cost. Small trials of β-blockers suggest that they may prevent cardiovascular events in patients undergoing noncardiac surgery, but trial results are inconclusive. We have initiated the POISE trial to definitively establish the effects of β-blocker therapy in patients undergoing noncardiac surgery. Methods: The POISE trial is a blinded, randomized, and controlled trial of controlled-release metoprolol versus placebo in 10000 patients at risk for a perioperative cardiovascular event who are undergoing noncardiac surgery. Patients will receive the study drug 2 to 4 hours before surgery and su..

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