Journal article

Extracorporeal Ammonia Clearance for Hyperammonemia in Critically Ill Patients: A Scoping Review

Thummaporn Naorungroj, Fumitaka Yanase, Glenn M Eastwood, Ian Baldwin, Rinaldo Bellomo



INTRODUCTION: Hyperammonemia is a life-threatening condition. However, clearance of ammonia via extracorporeal treatment has not been systematically evaluated. METHODS: We searched EMBASE and MEDLINE databases. We included all publications reporting ammonia clearance by extracorporeal treatment in adult and pediatric patients with clearance estimated by direct dialysate ammonia measurement or calculated by formula. Two reviewers screened and extracted data independently. RESULTS: We found 1,770 articles with 312 appropriate for assessment and 28 studies meeting eligibility criteria. Most of the studies were case reports. Hyperammonemia was typically secondary to inborn errors of metabolisms ..

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University of Melbourne Researchers