The rise and fall of bone marrow plasma cells after influenza vaccination

Abstract

A recent report by Davis et al. shows that following vaccination, B-cell activation results in the emergence of a population of antibody-secreting cells (plasmablasts - PBs) in blood and a population of plasma cells (PCs) in the bone marrow, which likely originate from the day 7 PBs. However, these newly arrived PCs do not become long-lived and their abundance decreases by 1 year post-vaccination.