Journal article

Computational identification of eukaryotic promoters based on cascaded deep capsule neural networks.

Yan Zhu, Fuyi Li, Dongxu Xiang, Tatsuya Akutsu, Jiangning Song, Cangzhi Jia

Brief Bioinform | Published : 2021

Abstract

A promoter is a region in the DNA sequence that defines where the transcription of a gene by RNA polymerase initiates, which is typically located proximal to the transcription start site (TSS). How to correctly identify the gene TSS and the core promoter is essential for our understanding of the transcriptional regulation of genes. As a complement to conventional experimental methods, computational techniques with easy-to-use platforms as essential bioinformatics tools can be effectively applied to annotate the functions and physiological roles of promoters. In this work, we propose a deep learning-based method termed Depicter (Deep learning for predicting promoter), for identifying three sp..

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University of Melbourne Researchers

Grants

Awarded by National Natural Scientific Foundation of China


Awarded by Fundamental Research Funds for the Central Universities


Awarded by National Natural Science Foundation of Liaoning Province


Awarded by National Health and Medical Research Council of Australia


Awarded by NIH HHS


Awarded by Collaborative Research Program of Institute for Chemical Research