Journal article

ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of A delta and C fiber sensory neurons that innervate bone

Michael Morgan, Jenny Thai, Phu Trinh, Mohamed Habib, Kelly N Effendi, Jason J Ivanusic

Molecular Pain | SAGE PUBLICATIONS INC | Published : 2020


The Acid Sensing Ion Channel 3 (ASIC3) is a non-selective cation channel that is activated by acidification, and is known to have a role in regulating inflammatory pain. It has pro-algesic roles in a range of conditions that present with bone pain, but the mechanism for this has not yet been demonstrated. We aimed to determine if ASIC3 is expressed in Aδ and/or C fiber bone afferent neurons, and to explore its role in the activation and sensitization of bone afferent neurons after acute inflammation. A combination of retrograde tracing and immunohistochemistry was used to determine expression of ASIC3 in the soma of bone afferent neurons. A novel, in vivo, electrophysiological bone-nerve pre..

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Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the Australian National Health and Medical Research Council.