Clinical Switching Strategies of Various Antidepressants to Vortioxetine in the PREDDICT Trial
Natalie T Mills, Emma Sampson, Celia Fourrier, Bernhard T Baune
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | OXFORD UNIV PRESS | Published : 2021
BACKGROUND: Partial response to antidepressant medication as well as relapse and treatment resistance are common in major depressive disorder (MDD). Therefore, for most patients with MDD, there will be a need to consider changing antidepressant medication at some stage during the course of the illness. The PREDDICT study investigates the efficacy of augmenting vortioxetine with celecoxib. METHODS: We describe the method used in the PREDDICT study to change participants, who were already taking antidepressant medication at the time of the screening visit, to vortioxetine. We used a cross-titration to change study participants to vortioxetine. RESULTS: Of a total of 122 study participants who ..View full abstract
We are grateful to the Fay Fuller Foundation, South Australia, who supported the study with an unrestricted educational grant. The funder had no impact on the study questions, the study design, analyses or outputs.