SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence
Rita A Busuttil, Joshy George, Colin M House, Stephen Lade, Catherine Mitchell, Natasha S Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, Alex Boussioutas
Gastric Cancer | SPRINGER | Published : 2020
OBJECTIVE: Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined by the increased invasion of cancer locally and is associated with higher metastatic potential. This study aimed to identify genes that were functional in the most fundamental hallmark of cancer, namely invasion. We then wanted to assess their value as biomarkers of gastric cancer progression and recurrence. DESIGN: Data from a cohort of patients profiled on cDNA expression arrays was interrogated using K-means analysis. This genomic approach classified the data based on patterns of gene expression allowing the identification of the genes most correlated with the ..View full abstract
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Awarded by NHMRC
This research was supported by funding from the Peter Mac Foundation (RB), VCA (Early Career Seed Grant to RB), No Stomach For Cancer Foundation (AB/RB), NHMRC grants ID454584 (AB), ID1030980 (AB), The Li Ka Shing Foundation (AB) and philanthropic funding from the Estate of George Wilson and an anonymous donor.