Journal article

Multi-stakeholder consensus on a target product profile for an HIV cure

Sharon R Lewin, Timothy Attoye, Cathy Bansbach, Brian Doehle, Karine Dube, Mark Dybul, Devi SenGupta, Adam Jiang, Rowena Johnston, Rosanne Lamplough, Joseph M McCune, Gary J Nabel, Thumbi Ndung'u, John Pottage, David Ripin, James F Rooney, Izukanji Sikazwe, Moses Nsubuga, Mitchell Warren, Steven G Deeks

The Lancet HIV | ELSEVIER INC | Published : 2021

Abstract

Developing a cure for HIV is a global priority. Target product profiles are a tool commonly used throughout the drug development process to align interested parties around a clear set of goals or requirements for a potential product. Three distinct therapeutic modalities (combination therapies, ex-vivo gene therapy, and in-vivo gene therapy) for a target product profile for an HIV cure were identified. Using a process of expert face-to-face consultation and an online Delphi consultation, we found a high degree of agreement regarding the criteria for the optimum target product profile. Although the minimum attributes for a cure were debated, the broad consensus was that an acceptable cure nee..

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University of Melbourne Researchers

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Funding Acknowledgements

The authors would like to acknowledge those who supported the 2019 Sunnylands Summit: The Path Toward Ending HIV (Matt Craven, Matthew Wilson, Wendy Wertheimer, Ellen LaPointe, Rob Fallon, Rosanne Lamplough) and those who attended (Sani Aliyu, Gregg H Alton, Francoise Barre-Sinoussi, Linda-Gail Bekker, Peter Cherutich, Francois Dabis, Steven G Deeks, Mark Dybul, Mark Feinberg, Diana Finzi, Maureen M Goodenow, Eric Goosby, Daria J Hazuda, George Jagoe, Rowena Johnston, Ambassador David J Lane (retired), Sharon Lewin, Mike McCune, Gary J Nabel, Thumbi Ndung'u, Moses Nsubuga, John Pottage, Ram Prasad, David Ripin, Yiming Shao, Izukanji Sikazwe, Elhadj As Sy, Joseph D Tucker, Jay Varma, Mitchell Warren, and Jack Whitescarver), many of whom contributed to the content and writing of this Review. The authors also acknowledge the support of the International AIDS Society and the Annenberg Trust at Sunnylands for hosting the meeting.