Journal article

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group

Jeanne Leerssen, Tessa F Blanken, Elena Pozzi, Neda Jahanshad, Lyubomir Aftanas, Ole A Andreassen, Bernhard T Baune, Ivan Brack, Angela Carballedo, Christopher RK Ching, Udo Dannlowski, Katharina Dohm, Verena Enneking, Elena Filimonova, Stella M Fingas, Thomas Frodl, Beata R Godlewska, Janik Goltermann, Ian H Gotlib, Dominik Grotegerd Show all

TRANSLATIONAL PSYCHIATRY | SPRINGERNATURE | Published : 2020

Abstract

It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of ..

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Grants

Awarded by European Research Council (ERC) under the European Union


Awarded by NIH Consortium grant


Awarded by Spanish Ministry of Health


Awarded by Wellcome Trust


Awarded by European Community


Awarded by Wellcome Trust Strategic Award


Awarded by German Research Foundation (DFG)


Awarded by NIMH grant


Awarded by German Research Foundation


Awarded by Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster


Awarded by Optimising Personalised Care, at scale, for Young People with Emerging Mood Disorders


Awarded by Russian Science Foundation


Awarded by UK Medical Research Council


Awarded by NIMH


Awarded by NIA


Awarded by NIH/NIMH


Awarded by NIH from the Big Data to Knowledge (BD2K) Program


Awarded by Wellcome Trust Strategic Award "STratifying Resilience and Depression Longitudinally" (STRADL)


Awarded by Federal Ministry of Education and Research (BMBF)


Awarded by Innovative Medical Research



Funding Acknowledgements

This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 671084 -INSOMNIA, J.L., T.F.B., E.J.W.V.S.) and from the VU University Amsterdam University Research Fellowships (J.L., T.F.B.). The ENIGMA-MDD Working Group is supported by NIH Consortium grant U54 EB020403, R01 MH116147, P41 EB015922 (P.M.T., N.J.) and R01 MH117601 (N.J., L.S.). This work was further supported by a "Miguel Servet-II" contract from the Spanish Ministry of Health (CP16-00020) and partly funded by PI13/01057 (M.J. P.), Wellcome Trust Grant 10436/Z/14/Z (A.M.M.), and the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 602450. This paper reflects only the author's views and the European Union is not liable for any use that may be made of the information contained therein. This work was also supported by a Wellcome Trust Strategic Award 104036/Z/14/Z and the IMAGEMEND grant (H.C.W.); Branch Out Neurological Foundation, Children's Hospital Aid Society (F.P.M.); Science Foundation Ireland (SFI) Professorship grant (T.F.); German Research Foundation (DFG, grant FOR2107 KR 3822/5-1 and KR 3822/7-2 to A.K.; DFG, grant FOR2107 KI 588/14-1 and KI 588/14-2 to T.K.; DFG, grant FOR2107 NE 2254/1-2 to I.N.; DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to U.D.); NIMH grant R01 085667, the Dunn Foundation and the Pat Rutherford, Jr. Endowed Chair in Psychiatry (J.C.S.); German Research Foundation (SFB-TRR58, Projects C09 and Z02 to U.D.) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (grant Dan3/012/17 to U.D.); Optimising Personalised Care, at scale, for Young People with Emerging Mood Disorders $951,005 over 5 years (2018-2022) (APP1136259, I.B.H.). Russian Science Foundation grant #16-15-00128 (L.A.); UK Medical Research Council, Grant number G0701421, (B.R.G.); NIMH Grants R01-MH59259 and R37MH101495 (I.H.G.); NIA T32AG058507, NIH/NIMH 5T32MH073526, NIH grant U54EB020403 from the Big Data to Knowledge (BD2K) Program (C.R.K.C.); Wellcome Trust Strategic Award "STratifying Resilience and Depression Longitudinally" (STRADL) Reference 104036/Z/14/Z (E.H.); Dr Mortimer and Theresa Sackler Foundation (M.A.H.); Innovative Medical Research (RE111604 and RE111722 to R.R.); Medical Review, Sogen-sha (N.W.); Alberta Children's Hospital Research Institute (Q.M.). MPIP data were in part provided by the Munich Antidepressant Response Signature study, supported by a grant of the Exzellenz-Stiftung of the Max Planck Society and funded by the Federal Ministry of Education and Research (BMBF) in the framework of the National Genome Research Network (NGFN), FKZ 01GS0481. Data were provided (in part) by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research and by the McDonnell Center for Systems Neuroscience at Washington University.