Journal article

Patterns of Load-to-Strength Ratios Along the Spine in a Population-Based Cohort to Evaluate the Contribution of Spinal Loading to Vertebral Fractures

Hossein Mokhtarzadeh, Dennis E Anderson, Brett T Allaire, Mary L Bouxsein

Journal of Bone and Mineral Research | WILEY | Published : 2020

Abstract

Vertebral fractures (VFx) are common among older adults. Epidemiological studies report high occurrence of VFx at mid-thoracic and thoracolumbar regions of the spine; however, reasons for this observation remain poorly understood. Prior reports of high ratios of spinal loading to vertebral strength in the thoracolumbar region suggest a possible biomechanical explanation. However, no studies have evaluated load-to-strength ratios (LSRs) throughout the spine for a large number of activities in a sizeable cohort. Thus, we performed a cross-sectional study in a sample of adult men and women from a population-based cohort to: 1) determine which activities cause the largest vertebral LSRs, and 2) ..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health


Awarded by National Space Biomedical Research Institute


Awarded by National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services


Funding Acknowledgements

We acknowledge funding from the National Institutes of Health (R01AR073019, R00AG042458) and National Space Biomedical Research Institute (NCC 9-58). This project includes data from the Framingham Heart Study of the National Heart Lung and Blood Institute of the National Institutes of Health and Boston University School of Medicine. This project has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under contract no. 75N92019D00031. Authors' Roles: Study design: HM, DEA, and MLB. Study conduct: HM and DEA. Data collection: MLB and BTA. Data analysis: HM, DEA, and BTA. Data interpretation: HM, DEA, BTA, and MLB. Drafting manuscript: HM and DEA. Revising manuscript content: HM, DEA, BTA, and MLB. Approving final version of manuscript: HM, DEA, BTA, and MLB. DEA takes responsibility for the integrity of the data analysis. Author Contributions: HM: Conceptualization; data curation; formal analysis; investigation; methodology; software; validation; visualization; writing-original draft; writing-review and editing. DEA: Conceptualization; data curation; formal analysis; funding acquisition; investigation; methodology; software; supervision; validation; visualization; writing-original draft; writing-review and editing. BTA: Data curation; investigation; software; validation; visualization; writing-review and editing. MLB: Conceptualization; funding acquisition; methodology; project administration; resources; supervision; writing-review and editing.