Use of a High-Protein Enteral Nutrition Formula to Increase Protein Delivery to Critically Ill Patients: A Randomized, Blinded, Parallel-Group, Feasibility Trial
Lee-Anne S Chapple, Matthew J Summers, Rinaldo Bellomo, Marianne J Chapman, Andrew R Davies, Suzie Ferrie, Mark E Finnis, Sally Hurford, Kylie Lange, Lorraine Little, Stephanie N O'Connor, Sandra L Peake, Emma J Ridley, Paul J Young, Patricia J Williams, Adam M Deane
Journal of Parenteral and Enteral Nutrition | WILEY | Published : 2020
BACKGROUND: International guidelines recommend critically ill adults receive more protein than most receive. We aimed to establish the feasibility of a trial to evaluate whether feeding protein to international recommendations would improve outcomes, in which 1 group received protein doses representative of international guideline recommendations (high protein) and the other received doses similar to usual practice. METHODS: We conducted a prospective, randomized, blinded, parallel-group, feasibility trial across 6 intensive care units. Critically ill, mechanically ventilated adults expected to receive enteral nutrition (EN) for ≥2 days were randomized to receive EN containing 63 or 100 g/L ..View full abstract
The TARGET Protein Feasibility Trial was funded by The Hospital Research Foundation Royal Adelaide Hospital Translational Grant (PI MJC, $250,000). Nutricia Research B.V. provided in-kind support for trial enteral nutrition formulas, blinding and labeling of formulas, and associated costs with delivery to participating sites. Representatives from Nutricia were provided the protocol prior to trial commencement and the manuscript prior to journal submission; however, neither Nutricia nor their representatives had input into study design or conduct of the trial; the collection, analysis, or interpretation of the data; or the approval of the manuscript for publication. No data were made available to Nutricia prior to the final manuscript being produced. The Royal Adelaide Hospital provided infrastructure and administrative support. L. S. Chapple is supported by an NHMRC Early Career Fellowship. E. J. Ridley is supported by an NHMRC Emerging Leadership Fellowship. P. J. Young is supported by a Health Research Council of New Zealand Clinical Research Practitioner Fellowship. A. M. Deane is supported by an NMHRC Career Development Fellowship.