Journal article

COVID-MATCH65-A prospectively derived clinical decision rule for severe acute respiratory syndrome coronavirus 2

Jason A Trubiano, Sara Vogrin, Olivia C Smibert, Nada Marhoon, Adrian A Alexander, Kyra YL Chua, Fiona L James, Nicholas RL Jones, Sam E Grigg, Cecilia LH Xu, Nasreen Moini, Sam R Stanley, Michael T Birrell, Morgan T Rose, Claire L Gordon, Jason C Kwong, Natasha E Holmes

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

OBJECTIVES: We report on the key clinical predictors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and present a clinical decision rule that can risk stratify patients for COVID-19. DESIGN, PARTICIPANTS AND SETTING: A prospective cohort of patients assessed for COVID-19 at a screening clinic in Melbourne, Australia. The primary outcome was a positive COVID-19 test from nasopharyngeal swab. A backwards stepwise logistic regression was used to derive a model of clinical variables predictive of a positive COVID-19 test. Internal validation of the final model was performed using bootstrapped samples and the model scoring derived from the coefficients, with modelling p..

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