Journal article

Recurrent pregnancy loss

Evdokia Dimitriadis, Ellen Menkhorst, Shigeru Saito, William H Kutteh, Jan J Brosens

Nature Reviews Disease Primers | NATURE RESEARCH | Published : 2020


Recurrent pregnancy loss is a distressing pregnancy disorder experienced by ~2.5% of women trying to conceive. Recurrent pregnancy loss is defined as the failure of two or more clinically recognized pregnancies before 20-24 weeks of gestation and includes embryonic and fetal losses. The diagnosis of an early pregnancy loss is relatively straightforward, although progress in predicting and preventing recurrent pregnancy loss has been hampered by a lack of standardized definitions, the uncertainties surrounding the pathogenesis and the highly variable clinical presentation. The prognosis for couples with recurrent pregnancy loss is generally good, although the likelihood of a successful pregna..

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Awarded by AMED

Awarded by Wellcome Trust Investigator Award

Funding Acknowledgements

E.D. was supported by a senior research fellowship from National Health and Medical Research of Australia (NHMRC) and E.D. and E.M. by a NHMRC research project grant. S.S. was supported by AMED under grant numbers JP18gk0110018h0003 and JP20gk0110047h0002. J.J.B. was supported by funds from the Tommy's National Miscarriage Research Centre and a Wellcome Trust Investigator Award (212233/Z/18/Z).