Journal article

Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses

Rubaiyea Farrukee, Malika Ait-Goughoulte, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Viruses | MDPI | Published : 2020


The paramyxo- and pneumovirus family includes a wide range of viruses that can cause respiratory and/or systemic infections in humans and animals. The significant disease burden of these viruses is further exacerbated by the limited therapeutics that are currently available. Host cellular proteins that can antagonize or limit virus replication are therefore a promising area of research to identify candidate molecules with the potential for host-targeted therapies. Host proteins known as host cell restriction factors are constitutively expressed and/or induced in response to virus infection and include proteins from interferon-stimulated genes (ISGs). Many ISG proteins have been identified bu..

View full abstract


Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This work was supported by Project Grant #1143154 from The National Health and Medical Research Council (NHMRC) of Australia. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health. Ruby Farrukee is funded by the Roche Postdoc Fellowship (RPF) program from Hoffmann-La Roche under the supervision of Patrick Reading (Academic side) and Malika Ait-Goughoulte (Roche scientist leader).