Journal article

(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

Nicholas G Welch, Wenyi Li, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Frontiers in Chemistry | FRONTIERS MEDIA SA | Published : 2020

Abstract

As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AMPs) represent a promising class of compounds to help address this global issue. AMPs are best-known for their membrane-disruptive mode of action leading to bacteria cell lysis and death. However, many AMPs are also known to be non-lytic and have intracellular modes of action. Proline-rich AMPs (PrAMPs) are one such class, that are generally membrane permeable and inhibit protein synthesis leading to a bactericidal outcome. PrAMPs are highly effective against Gram-negative bacteria and yet show very low toxicity against eukaryotic cells. Here, we review both the Pr..

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Awarded by NHMRC


Awarded by ARC


Awarded by Cancer Council Victoria


Funding Acknowledgements

NOBS is the recipient of NHMRC funding (APP1142472, APP1158841, APP1185426), ARC funding (DP160101312, LE200100163), Cancer Council Victoria funding (APP1163284), and Australian Dental Research. Funding for antimicrobial materials and research was also supported by the Centre for Oral Health Research at The Melbourne Dental School. JW is an NHMRC Principal Research Fellow (1117483). The studies undertaken in his laboratory were supported by an NHMRC Project grant (APP1158841). WL is the recipient of the 2019 Weary Dunlop Foundation grant and 2020 Early Career Researcher grant scheme of the University of Melbourne. Research at The Florey Institute of Neuroscience and Mental Health was supported by the Victorian Government Operational Infrastructure Support Program.