Journal article

Single-arm prospective interventional study assessing feasibility of using gallium-68 ventilation and perfusion PET/CT to avoid functional lung in patients with stage III non-small cell lung cancer

Nicholas Bucknell, Nicholas Hardcastle, Price Jackson, Michael Hofman, Jason Callahan, Peter Eu, Amir Iravani, Rhonda Lawrence, Olga Martin, Mathias Bressel, Beverley Woon, Benjamin Blyth, Michael MacManus, Keelan Byrne, Daniel Steinfort, Tomas Kron, Gerard Hanna, David Ball, Shankar Siva

BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2020

Abstract

BACKGROUND: In the curative-intent treatment of locally advanced lung cancer, significant morbidity and mortality can result from thoracic radiation therapy. Symptomatic radiation pneumonitis occurs in one in three patients and can lead to radiation-induced fibrosis. Local failure occurs in one in three patients due to the lungs being a dose-limiting organ, conventionally restricting tumour doses to around 60 Gy. Functional lung imaging using positron emission tomography (PET)/CT provides a geographic map of regional lung function and preclinical studies suggest this enables personalised lung radiotherapy. This map of lung function can be integrated into Volumetric Modulated Arc Therapy (VMA..

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Grants

Awarded by RANZCR


Awarded by Peter MacCallum Cancer Centre Foundation


Awarded by Cancer Australia Priority-drive Collaborative CancerResearch Scheme Grant 2013


Funding Acknowledgements

This work was supported by RANZCR grant number 2017/014, the Peter MacCallum Cancer Centre Foundation grant number 1709. NWB is the recipient of an Graduate Research Scholarship funded by the Australian Government. A Cancer Australia Priority-drive Collaborative CancerResearch Scheme Grant 2013, APP1060919, supported the development of V/Q PET/CT. This research was supported by the Cancer Trials Management Scheme Competitive Grants Programme, administered by Cancer Council Victoria.