Journal article

Population pharmacokinetics of ivermectin for the treatment of scabies in Indigenous Australian children

Amanda Gwee, Stephen Duffull, Xiao Zhu, Steven YC Tong, Noel Cranswick, Brett McWhinney, Jacobus Ungerer, Joshua Francis, Andrew C Steer

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

Ivermectin is a broad-spectrum antiparasitic agent used for the treatment and control of neglected tropical diseases. In Australia, ivermectin is primarily used for scabies and is licensed in children aged ≥5 years weighing >15 kg. However, young children, aged 15 kg. Doses of 200 μg/kg rounded to the nearest whole or half 3 mg tablet were given to children with scabies and ivermectin concentrations determined at two time points after dosing. A population pharmacokinetic model was developed using non-linear mixed effects modelling. A separate covariate database of children aged 2 to 4 years and weighing 5 years. The median simulated area under the concentration-time curve was 976 μg∙h/L. Usi..

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