Journal article

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

Wen Shi Lee, Kevin John Selva, Samantha Davis, Bruce Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah Kelly, Ebene Haycroft, Hyon-Xhi Tan, Jennifer Juno, Adam Wheatley, Mark Hogarth, Deborah Cromer, Miles Davenport, Amy Chung, Stephen Kent

Cold Spring Harbor Laboratory | Published : 2020

Abstract

The capacity of antibodies to engage with innate and adaptive immune cells via the Fc region is important in preventing and controlling many infectious diseases, and is likely critical in SARS-CoV-2 infection. The evolution of such antibodies during convalescence from COVID-19 is largely unknown. We developed novel assays to measure Fc-dependent antibody functions against SARS-CoV-2 spike (S)-expressing cells in serial samples from a cohort of 53 subjects primarily with mild-moderate COVID-19, out to a maximum of 149 days post-infection. We found that S-specific antibodies capable of engaging dimeric FcγRIIa and FcγRIIIa decayed linearly over time. S-specific antibody-dependent cellular cyto..

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