Journal article

Trimethylamine N-oxide (TMAO) Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults

Stephanie Andraos, Beatrix Jones, Katherine Lange, Susan A Clifford, Eric B Thorstensen, Jessica A Kerr, Melissa Wake, Richard Saffery, David P Burgner, Justin M O'Sullivan

Current Developments in Nutrition | OXFORD UNIV PRESS INC | Published : 2021

Abstract

Background: Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies have mainly been conducted in individuals with cardiometabolic disease, and studies in population-derived samples are limited. Objective: We aimed to investigate the associations between plasma TMAO concentrations and its precursors [carnitine, choline, betaine, and dimethylglycine (DMG)] with metabolic syndrome (MetS) scores, preclinical cardiovascular phenotypes, and inflammatory biomarkers (i.e. high-sensitivity C-reactive protein and serum glycoprotein acetyls) in a population-derived cohort of children and their parents. Method..

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