Journal article

Investigating White Matter Tract Microstructural Changes at Six-Twelve Weeks following Mild Traumatic Brain Injury: A Combined Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging Study

Lucy E Oehr, Joseph Yuan-Mou Yang, Jian Chen, Jerome J Maller, Marc L Seal, Jacqueline FI Anderson



Using diffusion-weighted imaging (DWI), research has demonstrated changes suggestive of damage to white matter tracts (WMT) following mild traumatic brain injury (mTBI). Yet due to the predominant use of the diffusion tensor imaging (DTI) model, which has numerous well-established limitations, it has not yet been possible to clearly examine the nature of changes to WMT microstructure following mTBI. This study used a second DWI-based technique, neurite orientation dispersion and density imaging (NODDI), in combination with DTI to measure microstructural changes within the corpus callosum, three long association and one projection WMTs at 6-12 weeks following mTBI, compared with matched traum..

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Funding Acknowledgements

This work was supported by the University of Melbourne [2017 MRGSS]. Imaging analysis was conducted within the Developmental Imaging research group, Murdoch Childrens Research Institute at the Children's MRI Centre, Royal Children's Hospital, Melbourne Victoria. This was supported by the Murdoch Childrens Research Institute, Royal Children's Hospital, The University of Melbourne Department of Paediatrics and the Victorian Government's Operational Infrastructure Support Program. This work was also part funded by a grant from the University of Melbourne, and the Royal Children's Hospital Foundation to Dr. Joseph Yuan-Mou Yang (RCH1000).