Thesis / Dissertation

Total synthesis of effectors for modulating the human immune system

Tram Thao Thanh Nguyen, Spencer Williams (ed.)

Published : 2020


Innate immunity is provided by a complex network of cells, soluble factors, and organs that respond immediately or within hours of the appearance of a stimulus in the body. Innate immune processes can involve recognition of metabolites, including those of self or microbial pathogens, by endogenously-expressed pattern recognition receptors. In this thesis, I explored the structure of different antigens that can be recognized by the innate immunity macrophage inducible C-type lectin receptor (Mincle), innate-like natural killer T (NKT) cell, and mucosal-associated invariant T (MAIT) cells. Chapter 2 describes the synthesis of acyl variants of cholesteryl and ergosteryl alpha-mannoside (CAMs ..

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University of Melbourne Researchers