Thesis / Dissertation

Investigating olfactory deficits as a preclinical marker of Parkinson's disease

Leah Catherine Beauchamp, Kevin Barnham (ed.)

Published : 2020

Abstract

Parkinson’s disease is the fastest growing neurological condition in the world, expected to affect more than 12 million people globally by 2040. Despite centuries of ground-breaking research, the diagnosis of Parkinson’s disease is unreliable and there are no disease-modifying therapeutics. This may be attributable to a focus on the movement disorders associated with disease, which present only after substantial neurodegeneration has occurred. This results in a late, inaccurate diagnosis which is problematic for the development and utilisation of neuroprotective therapies which need to be administered early. Although there has been recognition of non-motor aspects of Parkinson’s disease as e..

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