Journal article

The investigation of bone fracture healing under intramembranous and endochondral ossification

Smriti Ghimire, Saeed Miramini, Glenn Edwards, Randi Rotne, Jiake Xu, Peter Ebeling, Lihai Zhang

BONE REPORTS | ELSEVIER | Published : 2021

Abstract

After trauma, fractured bone starts healing directly through bone union or indirectly through callus formation process. Intramembranous and endochondral ossification are two commonly known mechanisms of indirect healing. The present study investigated the bone fracture healing under intramembranous and endochondral ossification by developing theoretical models in conjunction with performing a series of animal experiments. Using experimentally determined mean bone densities in sheep tibia stabilized by the Locking Compression Plate (LCP) fixation system, the research outcomes showed that intramembranous and endochondral ossification can be described by Hill Function with two unique sets of fu..

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Grants

Awarded by AOTRAUMA Asia Pacific


Awarded by AOA Research Foundation


Funding Acknowledgements

The authors would like to thank Johnson & Johnson Medical, The g (2015-2016), AOTRAUMA Asia Pacific (AOTAP14-02, 2014-2015) and AOA Research Foundation (Project grant 403) for their support.