Roger S McIntyre, Michael Berk, Elisa Brietzke, Benjamin I Goldstein, Carlos Lopez-Jaramillo, Lars Vedel Kessing, Gin S Malhi, Andrew A Nierenberg, Joshua D Rosenblat, Amna Majeed, Eduard Vieta, Maj Vinberg, Allan H Young, Rodrigo B Mansur
The Lancet | ELSEVIER SCIENCE INC | Published : 2020
Bipolar disorders are a complex group of severe and chronic disorders that includes bipolar I disorder, defined by the presence of a syndromal, manic episode, and bipolar II disorder, defined by the presence of a syndromal, hypomanic episode and a major depressive episode. Bipolar disorders substantially reduce psychosocial functioning and are associated with a loss of approximately 10-20 potential years of life. The mortality gap between populations with bipolar disorders and the general population is principally a result of excess deaths from cardiovascular disease and suicide. Bipolar disorder has a high heritability (approximately 70%). Bipolar disorders share genetic risk alleles with o..View full abstract
Awarded by Spanish Ministry of Science and Innovation
Awarded by Research of the Generalitat de Catalunya
Awarded by Health Department; CERCA Programme, Generalitat de Catalunya
EV thanks the Spanish Ministry of Science and Innovation (PI15/00283 and PI18/00805) integrated into the National I+D+I Plan (cofunded by ISCIII-FEDER, CIBERSAM, and the Comissionate for Universities) and Research of the Generalitat de Catalunya to the Bipolar Disorders Group (2017 SGR 1365) and the project SLT006/17/00357, from PERIS 2016-20 (Health Department; CERCA Programme, Generalitat de Catalunya). The views expressed in this Seminar are those of the authors and are not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health.