Journal article

Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity: a randomized crossover trial

Michael J Wheeler, Daniel J Green, Ester Cerin, Kathryn A Ellis, Ilkka Heinonen, Jaye Lewis, Louise H Naylor, Neale Cohen, Robyn Larsen, Paddy C Dempsey, Bronwyn A Kingwell, Neville Owen, David W Dunstan

International Journal of Behavioral Nutrition and Physical Activity | BMC | Published : 2020

Abstract

BACKGROUND: Postprandial glucose, insulin, and triglyceride metabolism is impaired by prolonged sitting, but enhanced by exercise. The aim of this study was to assess the effects of a continuous exercise bout with and without intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides. METHODS: Sedentary adults who were overweight to obese (n = 67; mean age 67 yr SD ± 7; BMI 31.2 kg∙m- 2 SD ± 4.1), completed three conditions: SIT: uninterrupted sitting (8-h, control); EX+SIT: sitting (1-h), moderate-intensity walking (30-min), uninterrupted sitting (6.5-h); EX+BR: sitting (1-h), moderate-intensity walking (30- min), sitting interrupted every 30-..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by ARC Future Fellowship


Awarded by NHMRC


Funding Acknowledgements

This work was funded by a project grant from the National Health and Medical Research Council of Australia (1062338) and supported in part by the Victorian Government's OIS Program. These funding bodies were independent to the design, implementation, and interpretation of the study. MJW was supported by the University of Western Australia and the Baker Heart and Diabetes Institute. IH was supported by the University of Turku, Hospital District of South-West Finland and the Juho Vainio Foundation. NC was supported by The Baker Heart and Diabetes Institute, and has received research support from Astra Zeneca, Novartis, Sanofi, Boerhinger Ingelheim. EC was supported by an ARC Future Fellowship (ARC FT140100085). PCD was supported by an NHMRC Early Career Fellowship (APP1142685). DJG was supported an NHMRC Principal Research Fellowship (APP1080914). DWD was supported by an NHMRC Senior Research Fellowship (APP1078360). BAK and NO were supported by NHMRC Senior Principal Research Fellowships (APP1059454 & APP1003960).