Genomic Epidemiology of the First Wave of SARS-CoV-2 in Italy
Francesca Di Giallonardo, Sebastian Duchene, Ilaria Puglia, Valentina Curini, Francesca Profeta, Cesare Camma, Maurilia Marcacci, Paolo Calistri, Edward C Holmes, Alessio Lorusso
Viruses | MDPI | Published : 2020
Italy was one of the first countries to experience a major epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with >1000 cases confirmed by 1 March 2020. However, virus genome sequence data is sparse and there has been only limited investigation of virus transmission across the country. Here, we provide the most extensive study to date of the genomic epidemiology of SARS-CoV-2 in Italy covering the first wave of infection. We generated 191 new full-length genomes, largely sampled from central Italy (Abruzzo), before, during, and after the enforcement of a nationwide "lockdown" (8 March-3 June). These were combined with 460 published SARS-CoV-2 sequences sampled across ..View full abstract
Awarded by Italian Ministry of Health
Awarded by Australian Research Council
A.L. was funded by the Italian Ministry of Health IZS AM 08/19 Ricerca Corrente 2019, NGS e diagnostica molecolare in Sanita Animale: Fast D2"recipient Alessio Lorusso, IZS AM Ricerca Corrente 05/20 "PanCO: epidemiologia e patogenesi dei coronavirus umani ed animali" recipient Alessio Lorusso. E.C.H. was funded by an Australian Research Council Australian Laureate Fellowship (FL17010002). S.D. was supported by the Australian Research Council (DE190100805).