Journal article

Exercise alters cardiovascular and renal pregnancy adaptations in female rats born small on a high-fat diet

Dayana Mahizir, Jessica F Briffa, Kristina Anevska, Glenn D Wadley, Karen M Moritz, Mary E Wlodek

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2021

Abstract

Intrauterine growth restriction programs adult cardiorenal disease, which may be exacerbated by pregnancy and obesity. Importantly, exercise has positive cardiovascular effects. This study determined if high-fat feeding exacerbates the known adverse cardiorenal adaptations to pregnancy in rats born small and whether endurance exercise can prevent these complications. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham (Control) surgery on embryonic day 18 (E18) in Wistar-Kyoto rats. Female offspring consumed a Chow or high-fat diet (HFD) from weaning and were randomly allocated to either a sedentary (Sedentary) or an exercise protocol at 16 wk; ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

This research was supported by the National Health and Medical Research Council (NHMRC) of Australia [APP1025426 (to M. E. Wlodek) and APP1045602 (to M. E. Wlodek and K. M. Mortiz)] and Diabetes Australia Research Trust Grant (to M. E. Wlodek, G. D. Wadley, and K. M. Mortiz). D. Mahizir has a Malaysia Government Scholarship and K. Anevskahas a La Trobe University Postgraduate Award. J. F. Briffa held a Faculty of Medicine, Dentistry and Health Sciences Postdoctoral Fellowship at the University of Melbourne. K. M. Mortiz was funded by a NHMRC Senior Research Fellowship.