Journal article

An intact membrane is essential for small extracellular vesicle-induced modulation of alpha-synuclein fibrillization

Cathryn L Ugalde, Shane E Gordon, Mitch Shambrook, Amirmohammad Nasiri Kenari, Bradley M Coleman, Matthew A Perugini, Victoria A Lawson, David I Finkelstein, Andrew F Hill

Journal of Extracellular Vesicles | TAYLOR & FRANCIS LTD | Published : 2020


The misfolding and fibrillization of the protein, α-synuclein (αsyn), is associated with neurodegenerative disorders referred to as the synucleinopathies. Understanding the mechanisms of αsyn misfolding is an important area of interest given that αsyn misfolding contributes to disease pathogenesis. While many studies report the ability of synthetic lipid membranes to modulate αsyn folding, there is little data pertaining to the mechanism(s) of this interaction. αSyn has previously been shown to associate with small lipid vesicles released by cells called extracellular vesicles (EVs) and it is postulated these interactions may assist in the spreading of pathological forms of this protein. Tog..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

National Health and Medical Research Council, Grant/Award Number: GNT1132604