Journal article

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R DiNardo, Jorge Dominguez-Andres, Raphael Duivenwoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L Jeffrey, Nargis Khan, Leo AB Joosten, Eva Kaufmann, Eicke Latz Show all

NATURE IMMUNOLOGY | NATURE RESEARCH | Published : 2021

Abstract

The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.