Journal article

Microemulsion-Assisted Templating of Metal-Stabilized Poly(ethylene glycol) Nanoparticles

Gan Lin, Christina Cortez-Jugo, Yi Ju, Quinn A Besford, Timothy M Ryan, Shuaijun Pan, Joseph J Richardson, Frank Caruso

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2021

Abstract

Poly(ethylene glycol) (PEG) is well known to endow nanoparticles (NPs) with low-fouling and stealth-like properties that can reduce immune system clearance in vivo, making PEG-based NPs (particularly sub-100 nm) of interest for diverse biomedical applications. However, the preparation of sub-100 nm PEG NPs with controllable size and morphology is challenging. Herein, we report a strategy based on the noncovalent coordination between PEG-polyphenolic ligands (PEG-gallol) and transition metal ions using a water-in-oil microemulsion phase to synthesize sub-100 nm PEG NPs with tunable size and morphology. The metal-phenolic coordination drives the self-assembly of the PEG-gallol/metal NPs: compl..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology


Awarded by National Health and Medical Research Council Senior Principal Research Fellowship


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology (project number CE140100036). F.C. acknowledges the award a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). Part of this research was conducted at the SAXS beamline at the Australian Synchrotron.