Journal article

Epigenetic differences at the HTR2A locus in progressive multiple sclerosis patients

Vicki E Maltby, Rodney A Lea, Sean Burnard, Alexandre Xavier, Thao Van Cao, Nicole White, Daniel Kennedy, Kira Groen, Katherine A Sanders, Rebecca Seeto, Samara Bray, Melissa Gresle, Louise Laverick, Helmut Butzkueven, Rodney J Scott, Jeannette Lechner-Scott

Scientific Reports | NATURE RESEARCH | Published : 2020


The pathology of progressive multiple sclerosis (MS) is poorly understood. We have previously assessed DNA methylation in the CD4+ T cells of relapsing-remitting (RR) MS patients compared to healthy controls and identified differentially methylated regions (DMRs) in HLA-DRB1 and RNF39. This study aimed to investigate the DNA methylation profiles of the CD4+ T cells of progressive MS patients. DNA methylation was measured in two separate case/control cohorts using the Illumina 450K/EPIC arrays and data was analysed with the Chip Analysis Methylation Pipeline (ChAMP). Single nucleotide polymorphisms (SNPs) were assessed using the Illumina Human OmniExpress24 arrays and analysed using PLINK. Ex..

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Awarded by Canadian Institutes of Health Research

Funding Acknowledgements

This study was supported by a grant from Multiple Sclerosis Research Australia (13-037, 14-027). RAL, VEM, RS and KAS are supported by fellowships from Multiple Sclerosis Research Australia. KAS was supported by a scholarship from the Trish foundation. VEM was supported by a fellowship from the Canadian Institutes of Health Research (320577).