Journal article

Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat

David K Wright, Jamie N Mayo, Mujun Sun, Terence J O'Brien, Sandy R Shultz

Scientific Reports | NATURE RESEARCH | Published : 2020

Abstract

Neurovascular injury has been proposed as a universal pathological hallmark of traumatic brain injury (TBI) with molecular markers of angiogenesis and endothelial function associated with injury severity and morbidity. Sex differences in the neurovasculature response post-TBI may contribute to the differences seen in how males and females respond to injury. Steady-state contrast enhanced magnetic resonance imaging (SSCE-MRI) can be used to non-invasively assess the neurovasculature and may be a useful tool in understanding and predicting outcomes post-TBI. Here we used SSCE-MRI to investigate the neurovasculature of male and female rats at 48 h after an experimental TBI, and how these change..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Health and Medical Research Council to SRS [Grant number: 1141643; fellowship: 1159645] and to DKW [Grant number: 1174040].