Journal article

The Challenge of Cartilage Integration: Understanding a Major Barrier to Chondral Repair

Anna Trengove, Claudia Di Bella, Andrea J O'Connor

Tissue Engineering Part B Reviews | MARY ANN LIEBERT, INC | Published : 2021


Articular cartilage defects caused by injury frequently lead to osteoarthritis, a painful and costly disease. Despite widely used surgical methods to treat articular cartilage defects and a plethora of research into regenerative strategies as treatments, long-term clinical outcomes are not satisfactory. Failure to integrate repair tissue with native cartilage is a recurring issue in surgical and tissue-engineered strategies, seeing eventual degradation of the regenerated or surrounding tissue. This review delves into the current understanding of why continuous and robust integration with native cartilage is so difficult to achieve. Both the intrinsic limitations of chondrocytes to remodel in..

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Funding Acknowledgements

This work was supported by The Victorian Medical Research Acceleration Fund, the Melbourne Medical School seeding grant, the Sylvia and Charles Viertel Charitable Foundation Clinical Investigator award, the Particulate Fluids Processing Center, and an Australian Government Research Training Program Scholarship.