Updated adolescent diagnostic criteria for polycystic ovary syndrome: impact on prevalence and longitudinal body mass index trajectories from birth to adulthood
Chau Thien Tay, Roger J Hart, Martha Hickey, Lisa J Moran, Arul Earnest, Dorota A Doherty, Helena J Teede, Anju E Joham
BMC Medicine | BMC | Published : 2020
BACKGROUND: Polycystic ovary syndrome (PCOS) is challenging to diagnose. While the 2003 Rotterdam criteria are widely used for adults, the 2018 international PCOS guideline recommended updated Rotterdam criteria with both hyperandrogenism and oligo-anovulation for adolescents based on evidence-informed expert consensus. This study compared the prevalence of PCOS using updated and original Rotterdam criteria in community-based adolescents and explored long-term body mass index (BMI) trajectories across different diagnostic phenotypes. METHODS: Overall, 227 postmenarchal adolescent females from the prospective cohort Raine Study undertook comprehensive PCOS assessment at age 14-16 years. Detai..View full abstract
Dr. Chau T Tay holds a scholarship from the Research Training Program Scholarship from the Commonwealth of Australia. Prof. Helena J Teede holds a NHMRC Medical Research Future Fund (MRFF) Fellowship. Dr. Anju E Joham holds a NHMRC Early Career Fellowship. Prof. Martha Hickey holds a NHMRC Practitioner Fellowship. A/Prof. Lisa J Moran holds a National Heart Foundation Future Leader Fellowship. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.