Multimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas.
Stephen J Price, Adam MH Young, William J Scotton, Jared Ching, Laila A Mohsen, Natalie R Boonzaier, Victoria C Lupson, John R Griffiths, Mary A McLean, Timothy J Larkin
Journal of Magnetic Resonance Imaging | Published : 2016
PURPOSE: To use perfusion and magnetic resonance (MR) spectroscopy to compare the diffusion tensor imaging (DTI)-defined invasive and noninvasive regions. Invasion of normal brain is a cardinal feature of glioblastomas (GBM) and a major cause of treatment failure. DTI can identify invasive regions. MATERIALS AND METHODS: In all, 50 GBM patients were imaged preoperatively at 3T with anatomic sequences, DTI, dynamic susceptibility perfusion MR (DSCI), and multivoxel spectroscopy. The DTI and DSCI data were coregistered to the spectroscopy data and regions of interest (ROIs) were made in the invasive (determined by DTI), noninvasive regions, and normal brain. Values of relative cerebral blood v..View full abstract
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