ACE2: from protection of liver disease to propagation of COVID-19
Fiona J Warner, Harinda Rajapaksha, Nicholas Shackel, Chandana B Herath
CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2020
Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the renin-angiotensin system (RAS). The classical RAS is driven by its key enzyme ACE and is pivotal in the regulation of blood pressure and fluid homeostasis. More recently, it has been recognised that the protective RAS regulated by ACE2 counterbalances many of the deleterious effects of the classical RAS. Studies in murine models demonstrated that manipulating the protective RAS can dramatically alter many diseases including liver disease. Liver-specific overexpression of ACE2 in mice with liver fibrosis has proved to be highly effective in an..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by funding from the National Health and Medical Research Council (NHMRC) of Australia [grant number APP1124125].