Journal article

Protein glycosylation in head and neck cancers: From diagnosis to treatment

Mohammad Rasheduzzaman, Arutha Kulasinghe, Riccardo Dolcetti, Liz Kenny, Newell W Johnson, Daniel Kolarich, Chamindie Punyadeera

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | ELSEVIER | Published : 2020

Abstract

Glycosylation is the most common post-translational modification (PTM) of proteins. Malignant tumour cells frequently undergo an alteration in surface protein glycosylation. This phenomenon is also common in cancers of the head and neck, most of which are squamous cell carcinomas (HNSCC). It affects cell functions, including proliferation, motility and invasiveness, thus increasing the propensity to metastasise. HNSCC represents the sixth most frequent malignancy worldwide. These neoplasms, which arise from the mucous membranes of the various anatomical subsites of the upper aero-digestive tract, are heterogeneous in terms of aetiology and clinico-pathologic features. With current treatments..

View full abstract

Grants

Awarded by Cancer Australia


Awarded by NHMRC ECF


Awarded by National Breast Cancer Foundation


Awarded by Cancer Council Queensland


Awarded by Australian Research Council Future Fellowship by the Australian Government


Funding Acknowledgements

Chamindie Punyadeera (CP) is receiving research-funding support from the Cancer Australia (APP1145657) and the Garnett Passe and Rodney Williams Foundation. NHMRC ECF to AK (APP1157741). National Breast Cancer Foundation (IIRS-18-047) and Cancer Council Queensland (APP1145758, APP1165064) to RD. This research is also supported by an Australian Government Research Training Program (RTP) Scholarship to Mohammad Rasheduzzaman (MR). DK is the recipient of an Australian Research Council Future Fellowship (project number FT160100344) funded by the Australian Government.