Dissecting the Multiplicity of Immune Effects of Immunosuppressive Drugs to Better Predict the Risk of de novo Malignancies in Solid Organ Transplant Patients
Michela Cangemi, Barbara Montico, Damiana A Fae, Agostino Steffan, Riccardo Dolcetti
Frontiers in Oncology | FRONTIERS MEDIA SA | Published : 2019
De novo malignancies constitute an emerging cause of morbidity after solid organ transplant (SOT), significantly affecting the long-term survival of transplant recipients. Pharmacologic immunosuppression may functionally impair the immunosurveillance in these patients, thereby increasing the risk of cancer development. Nevertheless, the multiplicity and heterogeneity of the immune effects induced by immunosuppressive drugs limit the current possibilities to reliably predict the risk of de novo malignancy in SOT patients. Therefore, there is the pressing need to better characterize the immune dysfunctions induced by the different immunosuppressive regimens administered to prevent allograft re..View full abstract
Awarded by National Breast Cancer Foundation
Awarded by Cancer Council Queensland
Awarded by Brain Tumor Charity
This study was supported by grants from National Breast Cancer Foundation (IIRS_18_047), Cancer Council Queensland (APP1145758), Brain Tumor Charity (495168), Brain Foundation, and Cure Brain Cancer Foundation.