Journal article

Dissecting the Multiplicity of Immune Effects of Immunosuppressive Drugs to Better Predict the Risk of de novo Malignancies in Solid Organ Transplant Patients

Michela Cangemi, Barbara Montico, Damiana A Fae, Agostino Steffan, Riccardo Dolcetti

Frontiers in Oncology | FRONTIERS MEDIA SA | Published : 2019

Abstract

De novo malignancies constitute an emerging cause of morbidity after solid organ transplant (SOT), significantly affecting the long-term survival of transplant recipients. Pharmacologic immunosuppression may functionally impair the immunosurveillance in these patients, thereby increasing the risk of cancer development. Nevertheless, the multiplicity and heterogeneity of the immune effects induced by immunosuppressive drugs limit the current possibilities to reliably predict the risk of de novo malignancy in SOT patients. Therefore, there is the pressing need to better characterize the immune dysfunctions induced by the different immunosuppressive regimens administered to prevent allograft re..

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Grants

Awarded by National Breast Cancer Foundation


Awarded by Cancer Council Queensland


Awarded by Brain Tumor Charity


Funding Acknowledgements

This study was supported by grants from National Breast Cancer Foundation (IIRS_18_047), Cancer Council Queensland (APP1145758), Brain Tumor Charity (495168), Brain Foundation, and Cure Brain Cancer Foundation.