Journal article

Epigenetic Patterns in Five-Year-Old Children Exposed to a Low Glycemic Index Dietary Intervention during Pregnancy: Results from the ROLO Kids Study

Aisling A Geraghty, Alex Sexton-Oates, Eileen C O'Brien, Richard Saffery, Fionnuala M McAuliffe

Nutrients | MDPI | Published : 2020


A range of in utero and early-life factors can influence offspring epigenetics, particularly DNA methylation patterns. This study aimed to investigate the influence of a dietary intervention and factors in pregnancy on offspring epigenetic profile at five years of age. We also explored associations between body composition and methylation profile in a cross-sectional analysis. Sixty-three five-year-olds were selected from the ROLO Kids Study, a Randomized controlled trial Of a LOw glycemic index dietary intervention from the second trimester of pregnancy. DNA methylation was investigated in 780,501 CpG sites in DNA isolated from saliva. Principal component analysis identified no association ..

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Awarded by European Union

Funding Acknowledgements

This study was funded by the Health Research Board Ireland, Health Research Centre for Health and Diet Research, The National Maternity Hospital Medical Fund, and the European Union's Seventh Framework Programme (FP7/2007-2013), project EarlyNutrition under grant agreement no. 289346. Richard Sa ffery is supported by a National Health and Medical Research Council (Australia) Senior Research Fellowship and the Victorian Government Operational Infrastructure support scheme.