De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications
Shuimu Lin, John D Wade, Shouping Liu
Accounts of Chemical Research | AMER CHEMICAL SOC | Published : 2021
ConspectusThe alarming rate at which pathogens are developing resistance to conventional antibiotics represents one of the major global challenges to public health care. The prevalence of multidrug-resistant microorganisms is a major impetus for the discovery and development of new antimicrobials. Nature has, to date, been the source of most of the antibiotics discovered and used, including cationic antimicrobial peptides (CAMPs). CAMPs are key components of the innate immune system that are widely found in humans, animals, plants, and microorganisms and that serve as a first line of defense for the host. The attractive features of CAMPs have led to their recognition as potential new antimic..View full abstract
Awarded by Talent Fund for High-Level University Construction of Guangzhou
Awarded by National Natural Science Foundation of China
Awarded by NHMRC
We thank all our co-workers and collaborators who contributed to the work described herein. We are grateful to the Talent Fund for High-Level University Construction of Guangzhou (B195002009029 and B195002009030), National Natural Science Foundation of China (21907019), NHMRC Project grant (APP1158841), and an NHMRC Principal Research Fellowship to J.D.W. (APP1117483).