Journal article
FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease
AS Januszewski, CJ Watson, V O’Neill, K McDonald, M Ledwidge, T Robson, AJ Jenkins, AC Keech, L McClements
Scientific Reports | NATURE PORTFOLIO | Published : 2020
Abstract
Type 2 diabetes (T2D) is associated with increased risk of cardiovascular disease (CVD). As disturbed angiogenesis and endothelial dysfunction are strongly implicated in T2D and CVD, we aimed to investigate the association between a novel anti-angiogenic protein, FK506-binding protein like (FKBPL), and these diseases. Plasma FKBPL was quantified by ELISA cross-sectionally in 353 adults, consisting of 234 T2D and 119 non–diabetic subjects with/without CVD, matched for age, BMI and gender. FKBPL levels were higher in T2D (adjusted mean: 2.03 ng/ml ± 0.90 SD) vs. non-diabetic subjects (adjusted mean: 1.79 ng/ml ± 0.89 SD, p = 0.02), but only after adjustment for CVD status. In T2D, FKBPL was ne..
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Awarded by Department for Employment and Learning, Northern Ireland
Funding Acknowledgements
This work was supported by the Faculty Collaboration Seed funding, Faculty of Medicine, Health, Life Sciences, Queen's University Belfast, Northern Ireland, United Kingdom (LM), the NHMRC Program grant to the NHMRC Clinical Trials Centre, and NHMRC Fellowships (ACK, AJJ), and the Health Research Board of Ireland, Grant number CSA-2012-36 (C.W, M.L, K.M).