FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease.
Andrzej S Januszewski, Chris J Watson, Vikki O'Neill, Kenneth McDonald, Mark Ledwidge, Tracy Robson, Alicia J Jenkins, Anthony C Keech, Lana McClements
Scientific Reports | Published : 2020
Type 2 diabetes (T2D) is associated with increased risk of cardiovascular disease (CVD). As disturbed angiogenesis and endothelial dysfunction are strongly implicated in T2D and CVD, we aimed to investigate the association between a novel anti-angiogenic protein, FK506-binding protein like (FKBPL), and these diseases. Plasma FKBPL was quantified by ELISA cross-sectionally in 353 adults, consisting of 234 T2D and 119 non-diabetic subjects with/without CVD, matched for age, BMI and gender. FKBPL levels were higher in T2D (adjusted mean: 2.03 ng/ml ± 0.90 SD) vs. non-diabetic subjects (adjusted mean: 1.79 ng/ml ± 0.89 SD, p = 0.02), but only after adjustment for CVD status. In T2D, FKBPL was ne..View full abstract
Awarded by Biotechnology and Biological Sciences Research Council