Thesis / Dissertation

Variation of the Microbiome in Paediatric Crohn’s Disease

Shivani Kansal, Anthony Catto-Smith (ed.)

Published : 2019

Abstract

Introduction: Crohn’s Disease (CD) is a chronic, relapsing condition of the human gastrointestinal system with several significant extraintestinal manifestations. It can affect any age group; 10% of patients being diagnosed prior to their 18th birthday. Pediatric CD is known to have a more severe and difficult to manage phenotype. A rising incidence has been observed in recent years although the disease phenotype has remained largely unchanged. There is a growing body of literature describing dysbiosis in patients with CD. Despite extensive research, the role and behaviour of the gut microbiome in pediatric CD is not well understood. Aims: We aimed to characterize the microbiome in patie..

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