Thesis / Dissertation

The Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL) Veterans study - Post traumatic stress disorder and risk of Alzheimer's disease

Alby Elias, Malcolm Hopwood (ed.)

Published : 2020

Abstract

Background Epidemiological studies have suggested an association between posttraumatic stress disorder (PTSD) and Alzheimer’s dementia in Vietnam veterans. These studies, however, did not use biomarkers of Alzheimer’s disease (AD) to either confirm the diagnosis or assess the relative prevalence of AD pathology when investigating the risk of dementia in PTSD. Aim This study aimed at testing the hypothesis that Vietnam veterans with combat PTSD have an increased risk for Alzheimer’s disease in comparison with veteran controls as measured by biomarkers such as amyloid-beta and tau retention in the brain and regional hypometabolism and atrophy. Method Vietnam veterans with a history of PTSD ..

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