Safety and efficacy of intravenous thrombolysis in stroke patients on prior antiplatelet therapy in the WAKE-UP trial.
Benedikt M Frey, Florent Boutitie, Bastian Cheng, Tae-Hee Cho, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Jens Fiehler, Ian Ford, Ivana Galinovic, Alina Königsberg, Josep Puig, Pascal Roy, Anke Wouters, Tim Magnus, Vincent Thijs, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza Show all
Neurol Res Pract | Published : 2020
Background: One quarter to one third of patients eligible for systemic thrombolysis are on antiplatelet therapy at presentation. In this study, we aimed to assess the safety and efficacy of intravenous thrombolysis in stroke patients on prescribed antiplatelet therapy in the WAKE-UP trial. Methods: WAKE-UP was a multicenter, randomized, double-blind, placebo-controlled clinical trial to study the efficacy and safety of MRI-guided intravenous thrombolysis with alteplase in patients with an acute stroke of unknown onset time. The medication history of all patients randomized in the WAKE-UP trial was documented. The primary safety outcome was any sign of hemorrhagic transformation on follow-up ..View full abstract