Journal article

Less Nocturnal Hypoglycemia but Equivalent Time in Range Among Adults with Type 1 Diabetes Using Insulin Pumps Versus Multiple Daily Injections

Sybil A McAuley, Sara Vogrin, Melissa H Lee, Barbora Paldus, Steven Trawley, Martin de Bock, Mary B Abraham, Leon A Bach, Morton G Burt, Neale D Cohen, Peter G Colman, Elizabeth A Davis, Christel Hendrieckx, D Jane Holmes-Walker, Alicia J Jenkins, Joey Kaye, Anthony C Keech, Kavita Kumareswaran, Richard J MacIsaac, Roland W McCallum Show all



Background: This prerandomization analysis from the Australian HCL-Adult trial (registration number: ACTRN12617000520336) compared masked continuous glucose monitoring (CGM) metrics among adults using insulin pumps versus multiple daily injections (MDIs), who were all self-monitoring blood glucose (SMBG). Methods: Adults with type 1 diabetes, using an insulin pump or MDIs without real-time CGM (and entering a trial of closed-loop technology), were eligible. MDI users were given an insulin dosage calculator. All participants received diabetes and carbohydrate-counting education, then wore masked CGM sensors for 3 weeks. Ethics Approval: HREC-D 088/16 Results: Adults using MDIs (n = 61) versus..

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Funding Acknowledgements

We are grateful to the study volunteers for their participation. We acknowledge support by trial nurses, diabetes educators, and dietitians at the clinical sites; and central support at the University of Sydney by trial monitors and biostatisticians. S.A.M. is supported by a JDRF Research Award. M.H.L. is supported by a National Health and Medical Research Council (NHMRC) postgraduate scholarship, cofunded by Diabetes Australia. B.P. is supported by University of Melbourne scholarships and research support from JDRF Australia. J.S. and C.H. are supported by core funding to the Australian Centre for Behavioural Research in Diabetes provided by the collaboration between Diabetes Victoria and Deakin University. A.J.J. is supported by an NHMRC Practitioner Fellowship and was a Sydney Medical School Foundation Fellow.