Journal article

Comparing 5-Year and Lifetime Risks of Breast Cancer using the Prospective Family Study Cohort.

Robert J MacInnis, Julia A Knight, Wendy K Chung, Roger L Milne, Alice S Whittemore, Richard Buchsbaum, Yuyan Liao, Nur Zeinomar, Gillian S Dite, Melissa C Southey, David Goldgar, Graham G Giles, Allison W Kurian, undefined kConFab Investigators, Irene L Andrulis, Esther M John, Mary B Daly, Saundra S Buys, Kelly-Anne Phillips, John L Hopper Show all

J Natl Cancer Inst | Published : 2021


BACKGROUND: Clinical guidelines often use predicted lifetime risk from birth to define criteria for making decisions regarding breast cancer screening rather than thresholds based on absolute 5-year risk from current age. METHODS: We used the Prospective Family Cohort Study of 14 657 women without breast cancer at baseline in which, during a median follow-up of 10 years, 482 women were diagnosed with invasive breast cancer. We examined the performances of the International Breast Cancer Intervention Study (IBIS) and Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk models when using the alternative thresholds by comparing predictions based on 5..

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