Elevated Serum Interleukin-1 beta Levels in Male, but not Female, Collision Sport Athletes with a Concussion History
William T O'Brien, Georgia F Symons, Jesse Bain, Brendan P Major, Daniel M Costello, Mujun Sun, Joshua S Kimpton, Zhibin Chen, Rhys D Brady, Richelle Mychasiuk, Terence J O'Brien, Mastura Monif, Sandy R Shultz, Stuart J McDonald
JOURNAL OF NEUROTRAUMA | MARY ANN LIEBERT, INC | Published : 2021
It is increasingly reported that a history of concussion may be associated with chronic deleterious consequences. While the pathophysiology that contributes to these consequences is not well understood, neuroinflammation is postulated to be critical. Activation of multi-protein complexes termed inflammasomes, a key component of this inflammatory response, has been reported in more severe TBIs; however, it has not been investigated in milder TBIs, such as concussion. This study investigated serum levels of interleukin (IL)-1β and IL-18 (key proteins activated downstream of these inflammasomes) at acute, sub-acute, and chronic time-points post-concussion. We recruited 105 Australian footballer..View full abstract
This study acknowledges research funding and support from Monash University and grants and fellowships awarded to S.R.S., T.O.B., and R.M. by the Australian National Health and Medical Research Council.