Local Secretory Trafficking Pathways in Neurons and the Role of Dendritic Golgi Outposts in Different Cell Models
Jingqi Wang, Lou Fourriere, Paul A Gleeson
FRONTIERS IN MOLECULAR NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2020
A fundamental characteristic of neurons is the relationship between the architecture of the polarized neuron and synaptic transmission between neurons. Intracellular membrane trafficking is paramount to establish and maintain neuronal structure; perturbation in trafficking results in defects in neurodevelopment and neurological disorders. Given the physical distance from the cell body to the distal sites of the axon and dendrites, transport of newly synthesized membrane proteins from the central cell body to their functional destination at remote, distal sites represents a conundrum. With the identification of secretory organelles in dendrites, including endoplasmic reticulum (ER) and Golgi ..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by funding from the National Health and Medical Research Council of Australia (APP1163862). JW was supported by a University of Melbourne International Postgraduate Award.