Journal article

Multiday cycles of heart rate are associated with seizure likelihood

Philippa Karoly, Rachel Stirling, Dean Freestone, Ewan Nurse, Matias Maturana, Amy Halliday, Andrew Neal, Nicholas Gregg, Benjamin Brinkmann, Mark Richardson, Sonya Dumanis, Andre La Gerche, David Grayden, Wendyl D’Souza, Mark Cook

Published : 2020


Circadian and multiday rhythms are found across many biological systems, including cardiology, endocrinology, neurology, and immunology. In people with epilepsy, epileptic brain activity and seizure occurrence have been found to follow circadian, weekly, and monthly rhythms. Understanding the relationship between these cycles of brain excitability and other physiological systems can provide new insight into the causes of multiday cycles. The brain-heart link is relevant for epilepsy, with implications for seizure forecasting, therapy, and mortality (i.e., sudden unexpected death in epilepsy). We report the results from a non-interventional, observational cohort study, Tracking Seizure Cycles..

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